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19-04-2025 | Review

The Associations Between Cognitive Flexibility and Suicidal Thoughts and Behaviors: A Systematic Review and Meta-Analysis

Auteurs: Yutong Zhu, Simon M. Li, Yifan Liu, Yancy Yanzhe Niu, Mark Shuquan Chen

Gepubliceerd in: Cognitive Therapy and Research

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Abstract

Purpose

Cognitive flexibility is associated with various psychological processes and outcomes. However, its relationship with suicidal thoughts and behaviors (STBs) remains inconclusive. Clarifying this relationship is vital, as cognitive flexibility—particularly set-shifting—may offer valuable insights into the cognitive mechanisms that could either heighten or reduce vulnerability to STBs. This systematic review and meta-analysis aimed to quantitatively assess this relationship.

Methods

We conducted a comprehensive search across four major databases (PubMed, PsycINFO, Web of Science, and Scopus) to identify studies measuring cognitive flexibility through validated self-report tools or experimental tasks in conjunction with STB assessments. A random-effects model was employed to analyze the data, with moderator analyses exploring potential sources of heterogeneity.

Results

The meta-analysis included 42 studies, comprising 5,946 participants. Results indicated a small but significant negative association between cognitive flexibility and STBs (r = − 0.132, k = 116, 95% CI [− 0.202; − 0.062], I2= 90.1%, Q(115) = 1157.75, p < 0.001). Subgroup analyses revealed no significant moderation effects by gender or age group, cognitive flexibility or STB measure type, whether the outcome was suicidal ideation or attempts, or clinical diagnoses.

Conclusions

These findings suggest that higher cognitive flexibility may act as a protective factor against STBs, possibly by promoting adaptive problem-solving and coping strategies, although the effect sizes remain small. We conclude that cognitive flexibility represents only a modest component in the etiology of STBs. Future research should focus on refining the measurement of cognitive flexibility in suicide risk assessments and incorporating these insights into intervention designs to evaluate its causal role.
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Literatuur
go back to reference Appelbaum, M., Cooper, H., Kline, R. B., Mayo-Wilson, E., Nezu, A. M., & Rao, S. M. (2018). Journal article reporting standards for quantitative research in psychology: The APA Publications and Communications Board task force report. American Psychologist, 73(1), 3–25. https://doi.org/10.1037/amp0000191CrossRefPubMed Appelbaum, M., Cooper, H., Kline, R. B., Mayo-Wilson, E., Nezu, A. M., & Rao, S. M. (2018). Journal article reporting standards for quantitative research in psychology: The APA Publications and Communications Board task force report. American Psychologist, 73(1), 3–25. https://​doi.​org/​10.​1037/​amp0000191CrossRefPubMed
go back to reference Bartfai, A., Winborg, I. M., Nordström, P., & Asberg, M. (1990). Suicidal behavior and cognitive flexibility: Design and verbal fluency after attempted suicide. Suicide and Lifethreatening Behavior, 20(3), 254–266.CrossRef Bartfai, A., Winborg, I. M., Nordström, P., & Asberg, M. (1990). Suicidal behavior and cognitive flexibility: Design and verbal fluency after attempted suicide. Suicide and Lifethreatening Behavior, 20(3), 254–266.CrossRef
go back to reference Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. John Wiley & Sons.CrossRef Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. John Wiley & Sons.CrossRef
go back to reference Fernández-Castilla, B., Declercq, L., Jamshidi, L., Beretvas, S. N., Onghena, P., & Van Den Noortgate, W. (2020). Visual representations of meta-analyses of multiple outcomes: Extensions to forest plots, funnel plots, and caterpillar plots. Methodology, 16(4), 299–315. https://doi.org/10.5964/meth.4013CrossRef Fernández-Castilla, B., Declercq, L., Jamshidi, L., Beretvas, S. N., Onghena, P., & Van Den Noortgate, W. (2020). Visual representations of meta-analyses of multiple outcomes: Extensions to forest plots, funnel plots, and caterpillar plots. Methodology, 16(4), 299–315. https://​doi.​org/​10.​5964/​meth.​4013CrossRef
go back to reference Fisher, R. A. (1921). On the “probable error” of a coefficient of correlation deduced from a small sample. Metron, 1, 3–32. Fisher, R. A. (1921). On the “probable error” of a coefficient of correlation deduced from a small sample. Metron, 1, 3–32.
go back to reference Gioia, G., Isquith, P., Guy, S., & Kenworthy, L. (2000). Behavior Rating Inventory of Executive Function (BRIEF). Lutz, FL: Psychological Assessment Resources. Gioia, G., Isquith, P., Guy, S., & Kenworthy, L. (2000). Behavior Rating Inventory of Executive Function (BRIEF). Lutz, FL: Psychological Assessment Resources.
go back to reference Hasse-Sousa, M., Martins, D. S., Petry-Perin, C., de Britto, M. J. S., Scheibe, D. B., Bücker, J., Gama, C. S., & Czepielewski, L. S. (2024). Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls. Journal of Affective Disorders Reports. https://doi.org/10.1016/j.jadr.2024.100773CrossRef Hasse-Sousa, M., Martins, D. S., Petry-Perin, C., de Britto, M. J. S., Scheibe, D. B., Bücker, J., Gama, C. S., & Czepielewski, L. S. (2024). Cognitive performance in bipolar disorder: Comparison between individuals with and without suicide attempts and healthy controls. Journal of Affective Disorders Reports. https://​doi.​org/​10.​1016/​j.​jadr.​2024.​100773CrossRef
go back to reference Heaton, R. K. (1981). Wisconsin card sorting test manual. Odessa, FL: Psychological Assessment Resources. Heaton, R. K. (1981). Wisconsin card sorting test manual. Odessa, FL: Psychological Assessment Resources.
go back to reference Jahn, D. R., Cukrowicz, K. C., Mitchell, S. M., Poindexter, E. K., & Guidry, E. T. (2015). The mediating role of perceived burdensomeness in relations between domains of cognitive functioning and indicators of suicide risk: Perceived burdensomeness, cognition, and suicide risk. Journal of Clinical Psychology, 71(9), 908–919. https://doi.org/10.1002/jclp.22190CrossRefPubMed Jahn, D. R., Cukrowicz, K. C., Mitchell, S. M., Poindexter, E. K., & Guidry, E. T. (2015). The mediating role of perceived burdensomeness in relations between domains of cognitive functioning and indicators of suicide risk: Perceived burdensomeness, cognition, and suicide risk. Journal of Clinical Psychology, 71(9), 908–919. https://​doi.​org/​10.​1002/​jclp.​22190CrossRefPubMed
go back to reference Jordan, J. T., Chick, C. F., Rolle, C. E., Hantke, N., Gould, C. E., Lutz, J., Kawai, M., Cotto, I., Karna, R., Pirog, S., Berk, M., Sudheimer, K., O’Hara, R., & Beaudreau, S. A. (2023). Neurocognitive markers of passive suicidal ideation in late-life depression. International Psychogeriatrics, 35(8), 421–431. https://doi.org/10.1017/S1041610220003610CrossRefPubMed Jordan, J. T., Chick, C. F., Rolle, C. E., Hantke, N., Gould, C. E., Lutz, J., Kawai, M., Cotto, I., Karna, R., Pirog, S., Berk, M., Sudheimer, K., O’Hara, R., & Beaudreau, S. A. (2023). Neurocognitive markers of passive suicidal ideation in late-life depression. International Psychogeriatrics, 35(8), 421–431. https://​doi.​org/​10.​1017/​S104161022000361​0CrossRefPubMed
go back to reference Kotov, R., Krueger, R. F., Watson, D., Achenbach, T. M., Althoff, R. R., Bagby, R. M., Brown, T. A., Carpenter, W. T., Caspi, A., Clark, L. A., & Eaton, N. R. (2017). The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies. Journal of Abnormal Psychology, 126(4), 454–477. https://doi.org/10.1037/abn0000258CrossRefPubMed Kotov, R., Krueger, R. F., Watson, D., Achenbach, T. M., Althoff, R. R., Bagby, R. M., Brown, T. A., Carpenter, W. T., Caspi, A., Clark, L. A., & Eaton, N. R. (2017). The Hierarchical Taxonomy of Psychopathology (HiTOP): A dimensional alternative to traditional nosologies. Journal of Abnormal Psychology, 126(4), 454–477. https://​doi.​org/​10.​1037/​abn0000258CrossRefPubMed
go back to reference MacPherson, H. A., Kudinova, A. Y., Schettini, E., Jenkins, G. A., Gilbert, A. C., Thomas, S. A., Kim, K. L., Radoeva, P. D., Fenerci, R. L. B., Yen, S., Hower, H., Hunt, J., Keller, M. B., & Dickstein, D. P. (2022a). Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder. European Child and Adolescent Psychiatry, 31(2), 299–312. https://doi.org/10.1007/s00787-020-01688-0CrossRefPubMed MacPherson, H. A., Kudinova, A. Y., Schettini, E., Jenkins, G. A., Gilbert, A. C., Thomas, S. A., Kim, K. L., Radoeva, P. D., Fenerci, R. L. B., Yen, S., Hower, H., Hunt, J., Keller, M. B., & Dickstein, D. P. (2022a). Relationship between cognitive flexibility and subsequent course of mood symptoms and suicidal ideation in young adults with childhood-onset bipolar disorder. European Child and Adolescent Psychiatry, 31(2), 299–312. https://​doi.​org/​10.​1007/​s00787-020-01688-0CrossRefPubMed
go back to reference Miranda, R., Gallagher, M., Bauchner, B., Vaysman, R., & Marroquín, B. (2012). Cognitive inflexibility as a prospective predictor of suicidal ideation among young adults with a suicide attempt history: Cognitive inflexibility and suicidal behavior. Depression and Anxiety, 29(3), 180–186. https://doi.org/10.1002/da.20915CrossRefPubMed Miranda, R., Gallagher, M., Bauchner, B., Vaysman, R., & Marroquín, B. (2012). Cognitive inflexibility as a prospective predictor of suicidal ideation among young adults with a suicide attempt history: Cognitive inflexibility and suicidal behavior. Depression and Anxiety, 29(3), 180–186. https://​doi.​org/​10.​1002/​da.​20915CrossRefPubMed
go back to reference Nagata, S., Seki, Y., Shibuya, T., Yokoo, M., Murata, T., Hiramatsu, Y., Yamada, F., Ibuki, H., Minamitani, N., Yoshinaga, N., Kusunoki, M., Inada, Y., Kawasoe, N., Adachi, S., Oshiro, K., Matsuzawa, D., Hirano, Y., Yoshimura, K., Nakazato, M.,… Shimizu, E. (2018). Does cognitive behavioral therapy alter mental defeat and cognitive flexibility in patients with panic disorder? BMC Research Notes, 11(1), 23. https://doi.org/10.1186/s13104-018-3130-2CrossRefPubMedPubMedCentral Nagata, S., Seki, Y., Shibuya, T., Yokoo, M., Murata, T., Hiramatsu, Y., Yamada, F., Ibuki, H., Minamitani, N., Yoshinaga, N., Kusunoki, M., Inada, Y., Kawasoe, N., Adachi, S., Oshiro, K., Matsuzawa, D., Hirano, Y., Yoshimura, K., Nakazato, M.,… Shimizu, E. (2018). Does cognitive behavioral therapy alter mental defeat and cognitive flexibility in patients with panic disorder? BMC Research Notes, 11(1), 23. https://​doi.​org/​10.​1186/​s13104-018-3130-2CrossRefPubMedPubMedCentral
go back to reference Onat, M., İnal Emiroğlu, N., Baykara, B., Özerdem, A., Özyurt, G., Öztürk, Y., Şahin, Ü., Ildız, A., Kaptancık Bilgiç, B., Hıdıroğlu Ongun, C., & Pekcanlar Akay, A. (2019). Executive functions and impulsivity in suicide attempter adolescents with major depressive disorder. Psychiatry and Clinical Psychopharmacology, 29(3), 332–339. https://doi.org/10.1080/24750573.2018.1541647CrossRef Onat, M., İnal Emiroğlu, N., Baykara, B., Özerdem, A., Özyurt, G., Öztürk, Y., Şahin, Ü., Ildız, A., Kaptancık Bilgiç, B., Hıdıroğlu Ongun, C., & Pekcanlar Akay, A. (2019). Executive functions and impulsivity in suicide attempter adolescents with major depressive disorder. Psychiatry and Clinical Psychopharmacology, 29(3), 332–339. https://​doi.​org/​10.​1080/​24750573.​2018.​1541647CrossRef
go back to reference Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S.,… Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. https://doi.org/10.1136/bmj.n71CrossRefPubMedPubMedCentral Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S.,… Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. https://​doi.​org/​10.​1136/​bmj.​n71CrossRefPubMedPubMedCentral
go back to reference Reitan, R. M. (1986). Trail making test: Manual for administration and scoring. Reitan Neuropsychology Laboratory. Reitan, R. M. (1986). Trail making test: Manual for administration and scoring. Reitan Neuropsychology Laboratory.
go back to reference Rosa-Alcázar, Á., Olivares-Olivares, P. J., Martínez-Esparza, I. C., Parada-Navas, J. L., Rosa-Alcázar, A. I., & Olivares-Rodríguez, J. (2020). Cognitive flexibility and response inhibition in patients with obsessive-compulsive disorder and generalized anxiety disorder. International Journal of Clinical and Health Psychology, 20(1), 20–28. https://doi.org/10.1016/j.ijchp.2019.07.006CrossRefPubMed Rosa-Alcázar, Á., Olivares-Olivares, P. J., Martínez-Esparza, I. C., Parada-Navas, J. L., Rosa-Alcázar, A. I., & Olivares-Rodríguez, J. (2020). Cognitive flexibility and response inhibition in patients with obsessive-compulsive disorder and generalized anxiety disorder. International Journal of Clinical and Health Psychology, 20(1), 20–28. https://​doi.​org/​10.​1016/​j.​ijchp.​2019.​07.​006CrossRefPubMed
Metagegevens
Titel
The Associations Between Cognitive Flexibility and Suicidal Thoughts and Behaviors: A Systematic Review and Meta-Analysis
Auteurs
Yutong Zhu
Simon M. Li
Yifan Liu
Yancy Yanzhe Niu
Mark Shuquan Chen
Publicatiedatum
19-04-2025
Uitgeverij
Springer US
Gepubliceerd in
Cognitive Therapy and Research
Print ISSN: 0147-5916
Elektronisch ISSN: 1573-2819
DOI
https://doi.org/10.1007/s10608-025-10591-4