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Journal of Autism and Developmental Disorders

Gepubliceerd in:

04-05-2018 | Original Paper

Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder

Auteurs: Molly B. D. Prigge, Erin D. Bigler, Brittany G. Travers, Alyson Froehlich, Tracy Abildskov, Jeffrey S. Anderson, Andrew L. Alexander, Nicholas Lange, Janet E. Lainhart, Brandon A. Zielinski

Gepubliceerd in: Journal of Autism and Developmental Disorders | Uitgave 10/2018

Abstract

The relationship between brain development and clinical heterogeneity in autism (ASD) is unknown. This study examines the Social Responsiveness Scale (SRS) in relation to the longitudinal development of cortical thickness. Participants (N = 91 ASD, N = 56 TDC; 3–39 years at first scan) were scanned up to three times over a 7-year period. Mixed-effects models examined cortical thickness in relation to SRS score. ASD participants with higher SRS scores showed regionally increased age-related cortical thinning. Regional thickness differences and reduced age-related cortical thinning were found in predominantly right lateralized regions in ASD with decreasing SRS scores over time. Our findings emphasize the importance of examining clinical phenotypes in brain-based studies of ASD.

vorige artikel Lack of Privileged Access to Awareness for Rewarding Social Scenes in Autism Spectrum Disorder

volgende artikel Autism and the University Experience: Narratives from Students with Neurodevelopmental Disorders

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Titel: Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder
Auteurs: Molly B. D. Prigge
Erin D. Bigler
Brittany G. Travers
Alyson Froehlich
Tracy Abildskov
Jeffrey S. Anderson
Andrew L. Alexander
Nicholas Lange
Janet E. Lainhart
Brandon A. Zielinski
Publicatiedatum: 04-05-2018
Uitgeverij: Springer US
Gepubliceerd in: Journal of Autism and Developmental Disorders / Uitgave 10/2018
Print ISSN: 0162-3257
Elektronisch ISSN: 1573-3432
DOI: https://doi.org/10.1007/s10803-018-3566-1

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Social Responsiveness Scale (SRS) in Relation to Longitudinal Cortical Thickness Changes in Autism Spectrum Disorder

Abstract

Andere artikelen Uitgave 10/2018

Student Perceptions of College-Readiness, College Services and Supports, and Family Involvement in College: An Exploratory Study

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The Effects of a Shared Reading Intervention on Narrative Story Comprehension and Task Engagement of Students with Autism Spectrum Disorder

Students with Autism Spectrum Disorder and Their Parents in the Transition into Higher Education: Impact on Dynamics in the Parent–Child Relationship

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