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23-08-2024

Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

Auteurs: Zhou Jin, Xuejian Liu, Haonan Guo, Sixuan Chen, Xianghe Zhu, Sipei Pan, Yili Wu

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 6/2024

Abstract

Telomere length, a biomarker of human aging, is related to adverse health outcomes. Growing evidence indicates that oxidative stress and inflammation contributes to telomere shortening, whereas social support may protect from telomere shortening. Despite sex differences in telomere length and social support, little is known about whether there are sex differences in the relationship between oxidative stress/inflammation and telomere length, and sex-specific moderating roles of social support in older adults. Using data from the National Health and Nutrition Examination Survey (NHANES) 1999–2002, this study assessed whether the associations between oxidative stress/inflammation and telomere length vary with sex and explored social support as a moderator in these associations among 2289 older adults. Oxidative stress was measured based on serum Gamma-glutamyl transferase (GGT), and inflammation was measured based on C-reactive protein (CRP). After adjusting for the covariates, GGT was significantly associated with telomere length in females only (β = − 0.037, 95% CI = − 0.070, − 0.005), while CRP was associated with telomere length in males only (β = − 0.019, 95% CI = − 0.035, − 0.002). Moreover, high social support mitigated the negative association between GGT and telomere length, which was more evident in females. Furthermore, social support moderated the association between CRP and telomere length in males aged 70 and above. Our findings indicated that biological mechanisms related to telomere length may vary with sex, while social support plays a sex-specific moderating role.

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Titel: Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults
Auteurs: Zhou Jin
Xuejian Liu
Haonan Guo
Sixuan Chen
Xianghe Zhu
Sipei Pan
Yili Wu
Publicatiedatum: 23-08-2024
Uitgeverij: Springer US
Gepubliceerd in: Journal of Behavioral Medicine / Uitgave 6/2024
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI: https://doi.org/10.1007/s10865-024-00515-0

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Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults

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