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11-04-2025 | Review

Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review

Auteurs: Siti Nur Akmal Ghazali, Hanani Abdul Manan, Caryn Mei Hsien Chan, Marfu’ah Nik Eezamuddeen, Noorazrul Yahya

Gepubliceerd in: Quality of Life Research

Abstract

Purpose

The association between health-related quality of life (HQoL) and overall survival (OS) among head and neck cancer (HNC) patients remains an important yet complex topic. This study aims to comprehensively analyze the prognostic effects of HQoL indices and symptoms-specific outcomes on overall survival in HNC patients.

Methods

A systematic literature search was conducted in PubMed, Web of Science and Scopus databases. The QUIPS tool was used to assess the risk of bias in the prognostic studies. The variables from the HQoL assessments included as predictors of OS were recorded. Different phases of measurements either pre or post-treatment (3 to > 12 months after completion) were also classified to observe the patterns. This review utilized a proposed best-evidence synthesis in which the consistency of significant results from multivariate analysis was observed. Each index that shows > 75% proportion of high-quality studies with same result is classified as strong evidence.

Results

Following an extensive search yielding 440 articles, the rigorous screening process identified 32 studies involving 12,206 HNC patients. This review underscores the pivotal role of higher post-treatment physical functioning predicting OS, which is supported by strong evidence and consistent findings. Three indices showed moderate evidence which are pretreatment physical function, post-treatment general HQoL and post-treatment social function. Notably, the analysis revealed that specific general-cancer symptoms, including appetite loss and dyspnea, were reported in association with OS in seven out of 33 instances, following multivariate analysis. Furthermore, the study highlighted the significance of social eating and problems with swallowing as predictors of OS (≥ 5 times instances) compared to other HNC symptoms-specific outcomes.

Conclusion

This study sheds light on the underexplored role of post-treatment physical function as predictors for OS, complementing the well-discussed pretreatment physical function. It identifies four specific symptoms significantly impacting OS, highlighting the need for effective management strategies.

Alleen toegankelijk voor geautoriseerde gebruikers

Chow, L. Q. M. (2020). Head and neck cancer. New England Journal of Medicine, 382(1), 60–72. https://doi.org/10.1056/NEJMra1715715CrossRefPubMed

Voon, N. S., Manan, H. A., & Yahya, N. (2023). Remote assessment of cognition and quality of life following radiotherapy for glioma: Deep-learning-based predictive models and MRI correlates. Journal of Neuro-Oncology, 162(2), 407–415. https://doi.org/10.1007/s11060-023-04303-9CrossRefPubMedPubMedCentral

Voon, N. S., Manan, H. A., & Yahya, N. (2023). Remote assessment of cognition and quality of life following radiotherapy for nasopharyngeal carcinoma: Deep-learning-based predictive models and MRI correlates [Article]. Journal of Cancer Survivorship. https://doi.org/10.1007/s11764-023-01371-8CrossRefPubMedPubMedCentral

Nazari, V., Pashaki, A. S., & Hasanzadeh, E. (2021). The reliable predictors of severe weight loss during the radiotherapy of head and neck cancer. Cancer Treatment and Research Communications, 26, 100281. https://doi.org/10.1016/j.ctarc.2020.100281CrossRefPubMed

Zalina Abu, Z., Neoh, M. K., & Mat, Z. A. (2022). Weight loss in post-chemoradiotherapy head and neck cancer patients. Nutrients, 14(3), 548. https://doi.org/10.3390/nu14030548CrossRef

Snider, J. W., 3rd., & Paine, C. C. (2020). Sticky stuff: xerostomia in patients undergoing head and neck radiotherapy-prevalence, prevention, and palliative care. Annals of Palliative Medicine, 9(3), 1340–1350. https://doi.org/10.21037/apm.2020.02.36CrossRefPubMed

Schulz, R. E., Bonzanini, L. I. L., Ortigara, G. B., Soldera, E. B., Danesi, C. C., Antoniazzi, R. P., & Ferrazzo, K. L. (2021). Prevalence of hyposalivation and associated factors in survivors of head and neck cancer treated with radiotherapy. Journal of Applied Oral Science : Revista Fob, 29, e20200854. https://doi.org/10.1590/1678-7757-2020-0854CrossRefPubMedPubMedCentral

Yahya, N., Mohamad Salleh, S. A., Mohd Nasir, N. F., & Abdul Manan, H. (2023). Toxicity profile of patients treated with proton and carbon-ion therapy for primary nasopharyngeal carcinoma: A systematic review and meta-analysis [Article]. Asia-Pacific Journal of Clinical Oncology. https://doi.org/10.1111/ajco.13915CrossRefPubMed

Yahya, N., & Manan, H. A. (2023). Quality of life and patient-reported outcomes following proton therapy for oropharyngeal carcinoma: A systematic review. Cancers, 15(8), 2252.CrossRefPubMedPubMedCentral

10.

Tirelli, G., Gatto, A., Bonini, P., Tofanelli, M., Arnež, Z. M., & Piccinato, A. (2018). Prognostic indicators of improved survival and quality of life in surgically treated oral cancer [Article]. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 126(1), 31–40. https://doi.org/10.1016/j.oooo.2018.01.016CrossRef

11.

Curran, D., Giralt, J., Harari, P. M., Ang, K. K., Cohen, R. B., Kies, M. S., Jassem, J., Baselga, J., Rowinsky, E. K., Amellal, N., Comte, S., & Bonner, J. A. (2007). Quality of life in head and neck cancer patients after treatment with high-dose radiotherapy alone or in combination with cetuximab. Journal of Clinical Oncology, 25(16), 2191–2197. https://doi.org/10.1200/JCO.2006.08.8005CrossRefPubMed

12.

Tiwana, M. S., Wu, J., Hay, J., Wong, F., Cheung, W., & Olson, R. A. (2014). 25 Year survival outcomes for squamous cell carcinomas of the head and neck: Population-based outcomes from a Canadian province. Oral Oncology, 50(7), 651–656. https://doi.org/10.1016/j.oraloncology.2014.03.009CrossRefPubMed

13.

Cheng, H. C., Yang, C. C., Kao, S. Y., Wu, T. Y., & Wu, C. H. (2020). Evaluation of factors associated with the risk stratification of survivorship for stage IV squamous cell carcinoma of the oral cavity: A 10-year retrospective study. Journal of the Chinese Medical Association, 83(5), 491–499. https://doi.org/10.1097/jcma.0000000000000292CrossRefPubMed

14.

Kanatas, A., Lowe, D., & Rogers, S. N. (2022). Health-related quality of life at 3 months following head and neck cancer treatment is a key predictor of longer-term outcome and of benefit from using the patient concerns inventory [Article]. Cancer Medicine, 11(8), 1879–1890. https://doi.org/10.1002/cam4.4558CrossRefPubMedPubMedCentral

15.

Thompson, T. L., Pagedar, N. A., Karnell, L. H., & Funk, G. F. (2011). Factors associated with mortality in 2-year survivors of head and neck cancer. Archives of Otolaryngology-Head & Neck Surgery, 137(11), 1100–1105. https://doi.org/10.1001/archoto.2011.179CrossRef

16.

Van Nieuwenhuizen, A. J., Buffart, L. M., Brug, J., Leemans, C. R., & Verdonck-De Leeuw, I. M. (2015). The association between health related quality of life and survival in patients with head and neck cancer: A systematic review [Review]. Oral Oncology, 51(1), 1–11. https://doi.org/10.1016/j.oraloncology.2014.09.002CrossRefPubMed

17.

Ghazali, S. N. A., Chan, C. M. H., Nik Eezamuddeen, M., Manan, H. A., & Yahya, N. (2023). Quality of life for head and neck cancer patients: A 10-year bibliographic analysis. Cancers (Basel), 15(18), 4551. https://doi.org/10.3390/cancers15184551CrossRefPubMed

18.

Noel, C. W., Forner, D., Wu, V., Enepekides, D., Irish, J. C., Husain, Z., Chan, K. K. W., Hallet, J., Coburn, N., & Eskander, A. (2020). Predictors of surgical readmission, unplanned hospitalization and emergency department use in head and neck oncology: A systematic review. Oral Oncology, 111, 105039. https://doi.org/10.1016/j.oraloncology.2020.105039CrossRefPubMed

19.

Kujan, O., Schaijik, B., & Farah, C. (2020). Immune checkpoint inhibitors in oral cavity squamous cell carcinoma and oral potentially malignant disorders: A systematic review. Cancers. https://doi.org/10.3390/cancers12071937CrossRefPubMedPubMedCentral

20.

Adeoye, J., Tan, J. Y., Choi, S. W., & Thomson, P. (2021). Prediction models applying machine learning to oral cavity cancer outcomes: A systematic review. International Journal of Medical Informatics, 154, 104557. https://doi.org/10.1016/j.ijmedinf.2021.104557CrossRefPubMed

21.

Chiang, C. L., Guo, Q., Ng, W. T., Lin, S., Ma, T. S. W., Xu, Z., Xiao, Y., Li, J., Lu, T., Choi, H. C. W., Chen, W., Chau, E. S. C., Luk, P. H. Y., Huang, S. H., O’Sullivan, B., Pan, J., & Lee, A. W. M. (2021). Prognostic factors for overall survival in nasopharyngeal cancer and implication for TNM staging by UICC: A systematic review of the literature [Systematic Review]. Fronters in Oncology. https://doi.org/10.3389/fonc.2021.703995CrossRef

22.

Singh, A., Uijtdewilligen, L., Twisk, J. W. R., van Mechelen, W., & Chinapaw, M. J. M. (2012). Physical activity and performance at school: A systematic review of the literature including a methodological quality assessment. Archives of Pediatrics & Adolescent Medicine, 166(1), 49–55. https://doi.org/10.1001/archpediatrics.2011.716CrossRef

23.

Jameson, M. J., Karnell, L. H., Christensen, A. J., & Funk, G. F. (2008). First-year trends in self-reported general health predict survival in patients with head and neck cancer [Article]. Archives of Otolaryngology - Head and Neck Surgery, 134(9), 958–964. https://doi.org/10.1001/archotol.134.9.958CrossRefPubMed

24.

Spiegel, D., & Kraemer, H. C. (2008). Emotional well-being does not predict survival in head and neck cancer patients: A radiation therapy oncology group study [Letter]. Cancer, 112(10), 2326–2327. https://doi.org/10.1002/cncr.23435CrossRefPubMed

25.

Quinten, C., Coens, C., Mauer, M., Comte, S., Sprangers, M. A. G., Cleeland, C., Osoba, D., Bjordal, K., & Bottomley, A. (2009). Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials. The Lancet Oncology, 10(9), 865–871. https://doi.org/10.1016/S1470-2045(09)70200-1CrossRefPubMed

26.

Quinten, C., Martinelli, F., Coens, C., Sprangers, M. A., Ringash, J., Gotay, C., Bjordal, K., Greimel, E., Reeve, B. B., Maringwa, J., Ediebah, D. E., Zikos, E., King, M. T., Osoba, D., Taphoorn, M. J., Flechtner, H., Schmucker-Von Koch, J., Weis, J., & Bottomley, A. (2014). A global analysis of multitrial data investigating quality of life and symptoms as prognostic factors for survival in different tumor sites. Cancer, 120(2), 302–311. https://doi.org/10.1002/cncr.28382CrossRefPubMed

27.

Aarstad, H. J., Osthus, A. A., Aarstad, H. H., Lybak, S., & Aarstad, A. K. H. (2019). EORTC Quality of Life Questionnaire Head and Neck (H&N)-35 scores from H&N squamous cell carcinoma patients obtained at diagnosis and at 6, 9 and 12 months following diagnosis predict 10-year overall survival. European Archives Of Oto-Rhino-Laryngology, 276(12), 3495–3505. https://doi.org/10.1007/s00405-019-05630-2CrossRefPubMed

28.

Aarstad, H. J., Sthus, A. A., Aarstad, H. H., Lybak, S., & Aarstad, A. K. H. (2018). General health-related quality of life scores from head and neck squamous cell carcinoma patients obtained throughout the first year following diagnosis predicted up to 10-year overall survival. European Archives Of Oto-Rhino-Laryngology, 275(1), 207–217. https://doi.org/10.1007/s00405-017-4800-8CrossRefPubMed

29.

Farrugia, M., Yu, H., Ma, S. J., Iovoli, A. J., Attwood, K., Wooten, K. E., Arshad, H., Gupta, V., McSpadden, R. P., Kuriakose, M. A., Markiewicz, M. R., Chan, J. M., Hicks, W. L., Platek, M. E., Ray, A. D., Repasky, E. A., & Singh, A. K. (2021). A principal component of quality of life measures is associated with survival for head and neck cancer patients treated with radiation therapy [Article]. Cancers, 13(5), 1–14. https://doi.org/10.3390/cancers13051155CrossRef

30.

Guo, S. S., Hu, W., Chen, Q. Y., Li, J. M., Zhu, S. H., He, Y., Li, J. W., Xia, L., Ji, L., Lin, C. Y., Liu, L. T., Tang, L. Q., Guo, L., Mo, H. Y., Zhao, C., Guo, X., Cao, K. J., Qian, C. N., Zeng, M. S., & Mai, H. Q. (2018). Pretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT. BMC Cancer, 18, 114. https://doi.org/10.1186/s12885-018-4003-8CrossRefPubMedPubMedCentral

31.

Kutz, L. M., Abel, J., Schweizer, D., Tribius, S., Krüll, A., Petersen, C., & Löser, A. (2022). Quality of life, HPV-status and phase angle predict survival in head and neck cancer patients under (chemo)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial [Article]. Radiotherapy And Oncology, 166, 145–153. https://doi.org/10.1016/j.radonc.2021.11.011CrossRefPubMed

32.

Tsai, W. L., Chien, C. Y., Huang, H. Y., Liao, K. C., & Fang, F. M. (2013). Prognostic value of quality of life measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma. Quality of Life Research, 22(4), 715–723. https://doi.org/10.1007/s11136-012-0213-8CrossRefPubMed

33.

Fang, F. M., Tsai, W. L., Chien, C. Y., Chen, H. C., Hsu, A. C., Huang, T. L., Lee, T. F., Huang, H. Y., & Lee, C. H. (2010). Pretreatment quality of life as a predictor of distant metastasis and survival for patients with nasopharyngeal carcinoma [Article]. Journal of Clinical Oncology, 28(28), 4384–4389. https://doi.org/10.1200/JCO.2010.28.8324CrossRefPubMed

34.

Nordgren, M., Abendstein, H., Jannert, M., Boysen, M., Ahlner-Elmqvist, M., Silander, E., Bjordal, K., & Hammerlid, E. (2003). Health-related quality of life five years after diagnosis of laryngeal carcinoma. International Journal of Radiation Oncology Biology Physics, 56(5), 1333–1343. https://doi.org/10.1016/S0360-3016(03)00292-XCrossRefPubMed

35.

Tarsitano, A., Pizzigallo, A., Ballone, E., & Marchetti, C. (2012). Health-related quality of life as a survival predictor for patients with oral cancer: is quality of life associated with long-term overall survival? Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 114(6), 756–763. https://doi.org/10.1016/j.oooo.2012.06.022CrossRefPubMed

36.

Hu, Z.-Y., Feng, X.-Q., Fu, M. R., Yu, R., & Zhao, H. L. (2020). Symptom patterns, physical function and quality of life among head and neck cancer patients prior to and after surgical treatment: A prospective study. European Journal of Oncology Nursing, 46, 101770. https://doi.org/10.1016/j.ejon.2020.101770CrossRefPubMed

37.

Nilsen, M. L., Mady, L. J., Hodges, J., Wasserman-Wincko, T., & Johnson, J. T. (2019). Burden of treatment: Reported outcomes in a head and neck cancer survivorship clinic. The Laryngoscope, 129(12), E437–E444. https://doi.org/10.1002/lary.27801CrossRefPubMed

38.

Avelar, J. M. P., Nicolussi, A. C., Toneti, B. F., Sonobe, H. M., & Sawada, N. O. (2019). Fatigue in patients with head and neck cancer undergoing radiation therapy: A prospective study. Revista Latino-Americana de Enfermagem, 27, e3168.CrossRefPubMedPubMedCentral

39.

Hammermüller, C., Hinz, A., Dietz, A., Wichmann, G., Pirlich, M., Berger, T., Zimmermann, K., Neumuth, T., Mehnert-Theuerkauf, A., Wiegand, S., & Zebralla, V. (2021). Depression, anxiety, fatigue, and quality of life in a large sample of patients suffering from head and neck cancer in comparison with the general population. BMC Cancer, 21(1), 94. https://doi.org/10.1186/s12885-020-07773-6CrossRefPubMedPubMedCentral

40.

Roick, J., Danker, H., Dietz, A., Papsdorf, K., & Singer, S. (2020). Predictors of changes in quality of life in head and neck cancer patients: A prospective study over a 6-month period. European Archives of Oto-Rhino-Laryngology, 277(2), 559–567. https://doi.org/10.1007/s00405-019-05695-zCrossRefPubMed

41.

Leão, I., Garcia, C., Antunes, P., Campolargo, A., Dias, I., Coimbra, E., Oliveira, P., Zenha, H., Costa, H., Capela, A., Viamonte, S., Alves, A. J., & Joaquim, A. (2022). Acute impact of cancer treatment on head and neck cancer patients: FIT4TREATMENT. Cancers, 14(11), 2698.CrossRefPubMedPubMedCentral

42.

Ohmae, N., Yasui-Yamada, S., Furumoto, T., Wada, K., Hayashi, H., Kitao, M., Yamanaka, A., Kubo, M., Matsuoka, M., Kamimura, S., Shimada, A., Sato, N., Kitamura, Y., Katoh, S., Takeda, N., & Hamada, Y. (2023). Muscle mass, quality, and strength; physical function and activity; and metabolic status in cachectic patients with head and neck cancer. Clinical Nutrition ESPEN, 53, 113–119. https://doi.org/10.1016/j.clnesp.2022.12.006CrossRefPubMed

43.

Rodriguez-Arietaleanizbeaskoa, M., Ereño, E. M., Arietaleanizbeaskoa, M. S., Grandes, G., Sánchez, A. R., Urquijo, V., Alday, I. H., Dublang, M., Angulo-Garay, G., & Cacicedo, J. (2023). Protocol for the SEHNeCa randomised clinical trial assesing supervised exercise for head and neck cancer patients. BMC Cancer, 23, 1–9. https://doi.org/10.1186/s12885-023-10718-4CrossRef

44.

Midgley, A. W., Levy, A. R., Rogers, S. N., Brooker, R. C., Bryant, V., Mary Gemma, C., Lane, S., Nugent, M. M., Price, R., Schache, A. G., Young, B., & Patterson, J. M. (2023). ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): Protocol for a feasibility study investigating a patient-centred approach to exercise for people with head and neck cancer. PLoS ONE. https://doi.org/10.1371/journal.pone.0289911CrossRefPubMedPubMedCentral

45.

Zhao, S. G., Alexander, N. B., Djuric, Z., Zhou, J., Tao, Y., Schipper, M., Feng, F. Y., Eisbruch, A., Worden, F. P., Strath, S. J., & Jolly, S. (2016). Maintaining physical activity during head and neck cancer treatment: Results of a pilot controlled trial. Head and Neck, 38(1), E1086-1096. https://doi.org/10.1002/hed.24162CrossRefPubMed

46.

Felser, S., Behrens, M., Liese, J., Strueder, D. F., Rhode, K., Junghanss, C., & Grosse-Thie, C. (2020). Feasibility and effects of a supervised exercise program suitable for independent training at home on physical function and quality of life in head and neck cancer patients: A pilot study. Integrative Cancer Therapies, 19, 1534735420918935. https://doi.org/10.1177/1534735420918935CrossRefPubMedPubMedCentral

47.

Nascimento Santos, E. L., Ferreira, I. B., Lajolo, P. P., Paiva, C. E., & de Paiva Maia, Y. C. (2020). Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study. Health and Quality of Life Outcomes, 18(1), 307. https://doi.org/10.1186/s12955-020-01543-5CrossRef

48.

So, W. K. W., Chan, R. J., Chan, D. N. S., Hughes, B. G. M., Chair, S. Y., Choi, K. C., & Chan, C. W. H. (2012). Quality-of-life among head and neck cancer survivors at one year after treatment – A systematic review. European Journal of Cancer, 48(15), 2391–2408. https://doi.org/10.1016/j.ejca.2012.04.005CrossRefPubMed

49.

Verdonck-de Leeuw, I. M., Korsten, L. H. A., van Nieuwenhuizen, A., Baatenburg de Jong, R. J., Brakenhoff, R. H., Buffart, L. M., Lamers, F., Langendijk, J. A., Leemans, C. R., Smit, J. H., Sprangers, M. A., Takes, R. P., Terhaard, C. H. J., Lissenberg-Witte, B. I., & Jansen, F. (2023). The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: The role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors. Supportive Care in Cancer, 31(8), 458. https://doi.org/10.1007/s00520-023-07918-wCrossRefPubMedPubMedCentral

50.

van Nieuwenhuizen, A. J., Buffart, L. M., Brug, J., René Leemans, C., & Verdonck-de Leeuw, I. M. (2015). The association between health related quality of life and survival in patients with head and neck cancer: A systematic review. Oral Oncology, 51(1), 1–11. https://doi.org/10.1016/j.oraloncology.2014.09.002CrossRefPubMed

51.

Bozec, A., Schultz, P., Gal, J., Chamorey, E., Chateau, Y., Dassonville, O., Poissonnet, G., Demard, F., Peyrade, F., Saada, E., Benezery, K., Leysalle, A., Santini, L., Messaoudi, L., & Fakhry, N. (2019). Evolution and predictive factors of quality of life in patients undergoing oncologic surgery for head and neck cancer: A prospective multicentric study. Surgical Oncology, 28, 236–242. https://doi.org/10.1016/j.suronc.2019.01.012CrossRefPubMed

52.

Jeffrey Lorenz, F. M., Tonya King, S. M. P., Linda Engle, B., Francis Beauchamp-Perez, M., & Neerav Goyal, M. M. F. (2023). Predictors of quality of life for head and neck cancer patients at an academic institution. OTO Open. https://doi.org/10.1002/oto2.82CrossRefPubMedPubMedCentral

53.

Cankovic, M., Tešić, M., Jevtić, M., Stevanović, D., Jovanovic, M. B., Kostić, D., Antic, J. A., & Trivić, S. K. (2022). Predictors of health-related quality of life in Serbian patients with head and neck cancer. Medicina Oral, Patología Oral y Cirugía Bucal, 27, e340–e350.CrossRefPubMedPubMedCentral

54.

Gimson, E., Greca Dottori, M., Clunie, G., Yan Zheng, C., Wiseman, T., Joyce, E., McGregor, A., & McNair, H. (2022). Not as simple as ’fear of the unknown: A qualitative study exploring anxiety in the radiotherapy department. European Journal of Cancer Care, 31(2), e13564. https://doi.org/10.1111/ecc.13564CrossRefPubMedPubMedCentral

55.

Holland, J. C., Andersen, B., Breitbart, W. S., Compas, B., Dudley, M. M., Fleishman, S., Fulcher, C. D., Greenberg, D. B., Greiner, C. B., Handzo, G. F., Hoofring, L., Jacobsen, P. B., Knight, S. J., Learson, K., Levy, M. H., Loscalzo, M. J., Manne, S., McAllister-Black, R., Riba, M. B., & Zevon, M. A. (2010). Distress management. Journal of the National Comprehensive Cancer Network, 8(4), 448–485. https://doi.org/10.6004/jnccn.2010.0034CrossRefPubMed

56.

McDowell, L., Rischin, D., Gough, K., & Henson, C. (2022). Health-related quality of life, psychosocial distress and unmet needs in older patients with head and neck cancer. Frontiers in Oncology, 12, 834068. https://doi.org/10.3389/fonc.2022.834068CrossRefPubMedPubMedCentral

57.

Chang, Y. L., Huang, B. S., Hung, T. M., Lin, C. Y., & Chen, S. C. (2019). Factors influencing body image in posttreatment oral cavity cancer patients. Psycho-Oncology, 28(5), 1127–1133. https://doi.org/10.1002/pon.5067CrossRefPubMed

58.

van Deudekom, F. J., Schimberg, A. S., Kallenberg, M. H., Slingerland, M., van der Velden, L.-A., & Mooijaart, S. P. (2017). Functional and cognitive impairment, social environment, frailty and adverse health outcomes in older patients with head and neck cancer, a systematic review. Oral Oncology, 64, 27–36. https://doi.org/10.1016/j.oraloncology.2016.11.013CrossRefPubMed

59.

Nightingale, C. L., Curbow, B. A., Wingard, J. R., Pereira, D. B., & Carnaby, G. D. (2016). Burden, quality of life, and social support in caregivers of patients undergoing radiotherapy for head and neck cancer: A pilot study. Chronic Illness, 12(3), 236–245. https://doi.org/10.1177/1742395316644305CrossRefPubMedPubMedCentral

60.

Koo, Y., Kim, E., Yelin, J., & Nam, I. (2023). Patient experience factors and implications for improvement based on the treatment journey of patients with head and neck cancer. Cancers, 15(8), 2265. https://doi.org/10.3390/cancers15082265CrossRefPubMedPubMedCentral

61.

Thome, N., Garcia, N., & Clark, K. (2018). Psychosocial needs of head and neck cancer patients and the role of the clinical social worker. Cancer Treatment and Research, 174, 237–248. https://doi.org/10.1007/978-3-319-65421-8_14CrossRefPubMed

62.

Bhardwaj, T. (2021). Quality of life of head and neck cancer patients: psychosocial perspective using mixed method approach. Indian Journal of Palliative Care, 27(2), 291–298. https://doi.org/10.25259/ijpc_108_21CrossRefPubMedPubMedCentral

63.

Graboyes, E. M., Maurer, S., Park, Y., Marsh, C. H., McElligott, J. T., Day, T. A., Hornig, J. D., & Sterba, K. R. (2020). Evaluation of a novel telemedicine-based intervention to manage body image disturbance in head and neck cancer survivors. Psycho-Oncology, 29(12), 1988–1994. https://doi.org/10.1002/pon.5399CrossRefPubMedPubMedCentral

64.

Saroul, N., Puechmaille, M., Lambert, C., Hassan, A. S., Biau, J., Lapeyre, M., Mom, T., Bernadach, M., & Gilain, L. (2021). Prognosis in Head and Neck Cancer: Importance of Nutritional and Biological Inflammatory Status. Otolaryngology-Head and Neck Surgery, 166(1), 118–127. https://doi.org/10.1177/01945998211004592CrossRefPubMed

65.

Caetano, R. S., Lima, F. F., Gomes, E. P., & Volpato, L. E. (2022). Quality of life of patients after treatment for cancer in the head and neck region: A case-control study. Cureus Journal of Medical Science, 14(6), e25800. https://doi.org/10.7759/cureus.25800CrossRef

66.

Dorr, M. C., Sewnaik, A., Berzenji, D., van Hof, K. S., Grevelink, T., de Jong, R. B. J., & Offerman, M. P. J. (2023). Learnings from longitudinal patient-reported and clinical outcomes in palliative head and neck cancer care. Otolaryngology-Head and Neck Surgery, 169(2), 294–302. https://doi.org/10.1177/01945998221127203CrossRefPubMed

67.

Van den Bosch, L., van der Laan, H. P., van der Schaaf, A., Oosting, S. F., Halmos, G. B., Witjes, M. J. H., Oldehinkel, E., Meijer, T. W. H., van den Hoek, J. G. M., Steenbakkers, R., & Langendijk, J. A. (2021). Patient-reported toxicity and quality-of-life profiles in patients with head and neck cancer treated with definitive radiation therapy or chemoradiation. International Journal of Radiation Oncology Biology Physics, 111(2), 456–467. https://doi.org/10.1016/j.ijrobp.2021.05.114CrossRefPubMed

68.

Mulasi, U., Vock, D. M., Jager-Wittenaar, H., Teigen, L., Kuchnia, A. J., Jha, G., Fujioka, N., Rudrapatna, V., Patel, M. R., & Earthman, C. P. (2020). Nutrition status and health-related quality of life among outpatients with advanced head and neck cancer. Nutrition In Clinical Practice, 35(6), 1129–1137. https://doi.org/10.1002/ncp.10476CrossRefPubMedPubMedCentral

69.

Asensi, M. T., Giangrandi, I., Sartini, L., Pagliai, G., Dinu, M., Lotti, S., Colombini, B., & Sofi, F. (2023). Quality of life and nutritional status of a group of post-operative head and neck cancer patients. Nutricion Hospitalaria, 40(5), 919–923. https://doi.org/10.20960/nh.04638CrossRef

70.

Carrillo, J. F., Carrillo, L. C., Ramirez-Ortega, M. C., Ochoa-Carrillo, F. J., & Oñate-Ocaña, L. F. (2016). The impact of treatment on quality of life of patients with head and neck cancer and its association with prognosis. European Journal of Surgical Oncology, 42(10), 1614–1621. https://doi.org/10.1016/j.ejso.2016.05.037CrossRefPubMed

71.

Osthus, A. A., Aarstad, A. K. H., Olofsson, J., & Aarstad, H. J. (2011). Head and neck specific health related quality of life scores predict subsequent survival in successfully treated head and neck cancer patients: A prospective cohort study [Article]. Oral Oncology, 47(10), 974–979. https://doi.org/10.1016/j.oraloncology.2011.07.010CrossRefPubMed

72.

Rogers, S. N., Waylen, A. E., Thomas, S., Penfold, C., Pring, M., Waterboer, T., Pawlita, M., Hurley, K., & Ness, A. R. (2020). Quality of life, cognitive, physical and emotional function at diagnosis predicts head and neck cancer survival: Analysis of cases from the Head and Neck 5000 study [Article]. European Archives of Oto-Rhino-Laryngology, 277(5), 1515–1523. https://doi.org/10.1007/s00405-020-05850-xCrossRefPubMedPubMedCentral

73.

Urba, S., Gatz, J., Shen, W., Hossain, A., Winfree, K., Koustenis, A., Peterson, P., & Cohen, E. E. W. (2012). Quality of life scores as prognostic factors of overall survival in advanced head and neck cancer: Analysis of a phase III randomized trial of pemetrexed plus cisplatin versus cisplatin monotherapy [Article]. Oral Oncology, 48(8), 723–729. https://doi.org/10.1016/j.oraloncology.2012.02.016CrossRefPubMed

74.

Yang, C. J., Roh, J. L., Kim, M. J., Lee, S. W., Kim, S. B., Choi, S. H., Nam, S. Y., & Kim, S. Y. (2016). Pretreatment quality of life as a prognostic factor for early survival and functional outcomes in patients with head and neck cancer [Article]. Quality of Life Research, 25(1), 165–174. https://doi.org/10.1007/s11136-015-1063-yCrossRefPubMed

75.

Coyne, J. C., Pajak, T. F., Harris, J., Konski, A., Movsas, B., Ang, K., & Watkins Bruner, D. (2007). Emotional well-being does not predict survival in head and neck cancer patients: A radiation therapy oncology group study. Cancer, 110(11), 2568–2575. https://doi.org/10.1002/cncr.23080CrossRefPubMed

76.

de Graeff, A., de Leeuw, J. R. J., Ros, W. J. G., Hordijk, G. J., Blijham, G. H., & Winnubst, J. A. M. (2001). Sociodemographic factors and quality of life as prognostic indicators in head and neck cancer. European Journal of Cancer, 37(3), 332–339. https://doi.org/10.1016/S0959-8049(00)00385-3CrossRefPubMed

77.

Fang, F. M., Liu, Y. T., Tang, Y., Wang, C. J., & Ko, S. F. (2004). Quality of life as a survival predictor for patients with advanced head and neck carcinoma treated with radiotherapy. Cancer, 100(2), 425–432. https://doi.org/10.1002/cncr.20010CrossRefPubMed

78.

Grignon, L. M., Jameson, M. J., Karnell, L. H., Christensen, A. J., & Funk, G. F. (2007). General health measures and long-term survival in patients with head and neck cancer. Archives of Otolaryngology Head and Neck Surgery, 133(5), 471–476. https://doi.org/10.1001/archotol.133.5.471CrossRefPubMed

79.

Karvonen-Gutierrez, C. A., Ronis, D. L., Fowler, K. E., Terrell, J. E., Gruber, S. B., & Duffy, S. A. (2008). Quality of life scores predict survival among patients with head and neck cancer. Journal of Clinical Oncology, 26(16), 2754–2760. https://doi.org/10.1200/JCO.2007.12.9510CrossRefPubMed

80.

Lango, M. N., Egleston, B., Fang, C., Burtness, B., Galloway, T., Liu, J., Mehra, R., Ebersole, B., Moran, K., & Ridge, J. A. (2014). Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer. Cancer, 120(6), 840–847. https://doi.org/10.1002/cncr.28482CrossRefPubMed

81.

Mehanna, H. M., & Morton, R. P. (2006). Does quality of life predict long-term survival in patients with head and neck cancer? Archives of Otolaryngology - Head and Neck Surgery, 132(1), 27–31. https://doi.org/10.1001/archotol.132.1.27CrossRefPubMed

82.

Meyer, F., Fortin, A., Gélinas, M., Nabid, A., Brochet, F., Têtu, B., & Bairati, I. (2009). Health-related quality of life as a survival predictor for patients with localized head and neck cancer treated with radiation therapy [Article]. Journal of Clinical Oncology, 27(18), 2970–2976. https://doi.org/10.1200/JCO.2008.20.0295CrossRefPubMed

83.

Nordgren, M., Jannert, M., Boysen, M., Ahlner-Elmqvist, M., Silander, E., Bjordal, K., & Hammerlid, E. (2006). Health-related quality of life in patients with pharyngeal carcinoma: A five-year follow-up. Head and Neck, 28(4), 339–349. https://doi.org/10.1002/hed.20334CrossRefPubMed

84.

Nordgren, M., Hammerlid, E., Bjordal, K., Ahlner-Elmqvist, M., Boysen, M., & Jannert, M. (2008). Quality of life in oral carcinoma: A 5-year prospective study. Head & Neck, 30(4), 461–470. https://doi.org/10.1002/hed.20735CrossRef

85.

Oskam, I. M., Verdonck-De Leeuw, I. M., Aaronson, N. K., Kuik, D. J., Bree, R. D., Doornaert, P., Langendijk, J. A., & Leemans, R. C. (2010). Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer [Article]. Radiotherapy and Oncology, 97(2), 258–262. https://doi.org/10.1016/j.radonc.2010.02.005CrossRefPubMed

86.

Osthus, A. A., Aarstad, A. K. H., Olofsson, J., & Aarstad, H. J. (2011). Health-related quality of life scores in long-term head and neck cancer survivors predict subsequent survival: A prospective cohort study [Article]. Clinical Otolaryngology, 36(4), 361–368. https://doi.org/10.1111/j.1749-4486.2011.02342.xCrossRefPubMed

87.

Osthus, A. A., Aarstad, A. K. H., Olofsson, J., & Aarstad, H. J. (2013). Prediction of survival by pretreatment health-related quality-of-life scores in a prospective cohort of patients with head and neck squamous cell carcinoma. JAMA Otolaryngology-Head & Neck Surgery, 139(1), 14–20. https://doi.org/10.1001/jamaoto.2013.1056CrossRef

88.

Siddiqui, F., Pajak, T. F., Watkins-Bruner, D., Konski, A. A., Coyne, J. C., Gwede, C. K., Garden, A. S., Spencer, S. A., Jones, C., & Movsas, B. (2008). Pretreatment Quality of Life Predicts for Locoregional Control in Head and Neck Cancer Patients: A Radiation Therapy Oncology Group Analysis. International Journal of Radiation Oncology Biology Physics, 70(2), 353–360. https://doi.org/10.1016/j.ijrobp.2007.06.024

Titel: Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review
Auteurs: Siti Nur Akmal Ghazali
Hanani Abdul Manan
Caryn Mei Hsien Chan
Marfu’ah Nik Eezamuddeen
Noorazrul Yahya
Publicatiedatum: 11-04-2025
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-025-03933-y

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Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review

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