Little research has examined health-related quality of life (HRQoL) in adults with learning disabilities in post-secondary settings and the potential relationship between a learning disability and anxiety or sadness. This study examined HRQoL in 68 undergraduate students: 34 students who reported having been diagnosed with a “learning disability” were compared to 34 students who indicated they had not been diagnosed with a learning disability. Participants completed an online survey of anxiety, sadness, and HRQoL, including the SF-36. ANCOVAs on the Emotional Well-Being and Role Limitations Due to Emotional Problems scales from the SF-36 revealed that students reporting a diagnosis of a learning disability were significantly more impaired in Emotional Well-Being. Regression analyses suggested that impairment in Emotional Well-Being was mediated by separate ratings of both anxiety and sadness. Results indicated that those undergraduates reporting learning disabilities suffered from an impaired sense of well-being associated with anxious and sad feelings.