A six-year-old girl with a history of asthma, died because of acute bronchoconstriction. Risk factors for fatal asthma are previous respiratory insufficiency, severe asthma, poor perception of dyspnea, misuse of β2-agonists without sufficient anti-inflammatory therapy during exacerbation, undertreatment, poor insight in disease and patient delay. Adequate therapy, recognition of risk factors, regular check-up and clear and written instruction to parents how to handle in case of dyspnea of their child is important in the prevention of fatal asthma.