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Quality of Life Research
Gepubliceerd in:

03-12-2018

Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery

Auteurs: C. Quinten, C. Kenis, L. Decoster, P. R. Debruyne, I. De Groof, C. Focan, F. Cornelis, V. Verschaeve, C. Bachmann, D. Bron, S. Luce, G. Debugne, H. Van den Bulck, J. C. Goeminne, A. Baitar, K. Geboers, B. Petit, C. Langenaeken, R. Van Rijswijk, P. Specenier, G. Jerusalem, J. P. Praet, K. Vandenborre, M. Lycke, J. Flamaing, K. Milisen, J. P. Lobelle, H. Wildiers

Gepubliceerd in: Quality of Life Research | Uitgave 3/2019

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Abstract

Purpose

Using the EORTC Global Health Status (GHS) scale, we aimed to determine minimal clinically important differences (MCID) in health-related quality of life (HRQOL) changes for older cancer patients with a geriatric risk profile, as defined by the geriatric 8 (G8) health screening tool, undergoing treatment. Simultaneously, we assessed baseline patient characteristics prognostic for HRQOL changes.

Methods

Our analysis included 1424 (G8 ≤ 14) older patients with cancer scheduled to receive chemotherapy (n = 683) or surgery (n = 741). Anchor-based methods, linking the GHS score to clinical indicators, were used to determine MCID between baseline and follow-up at 3 months. A threshold of 0.2 standard deviation (SD) was used to exclude MCID estimates too small for interpretation. Logistic regressions analysed baseline patient characteristics prognostic for HRQOL changes.

Results

The 15-item Geriatric Depression Scale (GDS15), Visual Analogue Scale (VAS) for Fatigue and ECOG Performance Status (PS) were selected as clinical anchors. In the surgery group, MCID estimates for improvement and deterioration were ECOG PS (5*, 11*), GDS15 (5*, 2) and VAS Fatigue (3, 9*). In the chemotherapy group, MCID estimates for improvement and deterioration were ECOG PS (8*, 7*), GDS15 (5, 4) and VAS Fatigue (5, 5*). Estimates with * were > 0.2 SD threshold. Patients experiencing pain or malnutrition (surgery group) or fatigue (chemotherapy group) at baseline showed a significantly stable or improved HRQOL (p < 0.05) after their treatment.

Conclusion

The reported MCID for improvement and deterioration depended on the anchor used and treatment received. The estimates can be used to evaluate significant changes in HRQOL and to determine sample sizes in clinical trials.
vorige artikel Pre-injury health status of injured patients: a prospective comparison with the Dutch population
volgende artikel Early quality-of-life and psychological predictors of disease-free time and survival in localized prostate cancer
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Metagegevens
Titel
Determining clinically important differences in health-related quality of life in older patients with cancer undergoing chemotherapy or surgery
Auteurs
C. Quinten
C. Kenis
L. Decoster
P. R. Debruyne
I. De Groof
C. Focan
F. Cornelis
V. Verschaeve
C. Bachmann
D. Bron
S. Luce
G. Debugne
H. Van den Bulck
J. C. Goeminne
A. Baitar
K. Geboers
B. Petit
C. Langenaeken
R. Van Rijswijk
P. Specenier
G. Jerusalem
J. P. Praet
K. Vandenborre
M. Lycke
J. Flamaing
K. Milisen
J. P. Lobelle
H. Wildiers
Publicatiedatum
03-12-2018
Uitgeverij
Springer International Publishing
Gepubliceerd in
Quality of Life Research / Uitgave 3/2019
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-018-2062-6

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