Skip to main content

Welkom bij Erasmus MC & Bohn Stafleu van Loghum

Erasmus MC heeft ervoor gezorgd dat je Mijn BSL eenvoudig en snel kunt raadplegen. Je kunt je links eenvoudig registreren. Met deze gegevens kun je thuis, of waar ook ter wereld toegang krijgen tot Mijn BSL.

Registreer

Om ook buiten de locaties van Erasmus MC, thuis bijvoorbeeld, van Mijn BSL gebruik te kunnen maken, moet je jezelf eenmalig registreren. Dit kan alleen vanaf een computer op een van de locaties van Erasmus MC.

Eenmaal geregistreerd kun je thuis of waar ook ter wereld onbeperkt toegang krijgen tot Mijn BSL.

Login

Als u al geregistreerd bent, hoeft u alleen maar in te loggen om onbeperkt toegang te krijgen tot Mijn BSL.

Top
Gepubliceerd in:

01-04-2006 | Artikel

De oudere patiënt met hartfalen en de rol van bètablokkers bij de behandeling

Auteurs: C. W. Middeljans-Tijssen, R. W. M. M. Jansen

Gepubliceerd in: Tijdschrift voor Gerontologie en Geriatrie | Uitgave 2/2006

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail

samenvatting

In this article different aspects of chronic heart failure in old age are described. We mainly focus on the place of beta-blocker therapy in chronic heart failure. Beta-blockers are recommended for the treatment of stable chronic heart failure with left ventricular systolic dysfunction. There is additional information from recent studies that there is proven efficacy for beta-blocker therapy in patients with heart failure up to the age of 80 years. For patients with heart failure aged 80 and over the evidence to prescribe beta-blockers is limited. However, it is known that also in very elderly patients beta-blocker therapy is well tolerated. In patients with heart failure with preserved systolic ventricular function there is still no evidence that there is a beneficial effect of beta-blockers. It is still not clear if there are differences between beta-blocking agents. Of all beta-blockers, only bisoprolol, carvedilol, nebivolol and metoprolol CR are proven effective in stable chronic heart failure with impaired left ventricular systolic function and can be recommended in elderly patients on standard treatment with diuretics and ACE inhibition.
Literatuur
go back to reference CBO. Multidisciplinaire richtlijn Chronisch Hartfalen. 2002. CBO. Multidisciplinaire richtlijn Chronisch Hartfalen. 2002.
go back to reference Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J 2004; 25(18):1614-1619.CrossRefPubMed Bleumink GS, Knetsch AM, Sturkenboom MC, Straus SM, Hofman A, Deckers JW et al. Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur Heart J 2004; 25(18):1614-1619.CrossRefPubMed
go back to reference Linden MW van der, Wester GP BDdSF, NIVEL RvVeM. Tweede Nationale Studie naar ziekten en verrichtingen in de huisartsenpraktijk:klachten en aandoeningen in de bevolking en in de huisartsenpraktijk. 2004. Utrecht, Bilthoven. Linden MW van der, Wester GP BDdSF, NIVEL RvVeM. Tweede Nationale Studie naar ziekten en verrichtingen in de huisartsenpraktijk:klachten en aandoeningen in de bevolking en in de huisartsenpraktijk. 2004. Utrecht, Bilthoven.
go back to reference Rutten HF, Walma EP, Kruizinga GI, Bakx HCA, van Lieshout J. NHG Standaard hartfalen (eerste herziening). Huisarts Wet [48], 64-76. 2005. Rutten HF, Walma EP, Kruizinga GI, Bakx HCA, van Lieshout J. NHG Standaard hartfalen (eerste herziening). Huisarts Wet [48], 64-76. 2005.
go back to reference Senni M, Redfield MM. Heart failure with preserved systolic function. A different natural history? J Am Coll Cardiol 2001; 38(5):1277-1282.CrossRefPubMed Senni M, Redfield MM. Heart failure with preserved systolic function. A different natural history? J Am Coll Cardiol 2001; 38(5):1277-1282.CrossRefPubMed
go back to reference Vasan RS, Larson MG, Benjamin EJ, Evans JC, Reiss CK, Levy D. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol 1999; 33(7):1948-1955.CrossRefPubMed Vasan RS, Larson MG, Benjamin EJ, Evans JC, Reiss CK, Levy D. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol 1999; 33(7):1948-1955.CrossRefPubMed
go back to reference Kupari M, Lindroos M, Iivanainen AM, Heikkila J, Tilvis R. Congestive heart failure in old age: prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study. J Intern Med 1997; 241(5):387-394.CrossRefPubMed Kupari M, Lindroos M, Iivanainen AM, Heikkila J, Tilvis R. Congestive heart failure in old age: prevalence, mechanisms and 4-year prognosis in the Helsinki Ageing Study. J Intern Med 1997; 241(5):387-394.CrossRefPubMed
go back to reference Hogg K, Swedberg K, McMurray J. Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol 2004; 43(3):317-327.CrossRefPubMed Hogg K, Swedberg K, McMurray J. Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol 2004; 43(3):317-327.CrossRefPubMed
go back to reference Vasan RS, Levy D. Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation 2000; 101(17):2118-2121.PubMed Vasan RS, Levy D. Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation 2000; 101(17):2118-2121.PubMed
go back to reference van Kraaij DJ, van Pol PE, Ruiters AW, de Swart JB, Lips DJ, Lencer N et al. Diagnosing diastolic heart failure. Eur J Heart Fail 2002; 4(4):419-430.CrossRefPubMed van Kraaij DJ, van Pol PE, Ruiters AW, de Swart JB, Lips DJ, Lencer N et al. Diagnosing diastolic heart failure. Eur J Heart Fail 2002; 4(4):419-430.CrossRefPubMed
go back to reference Lenzen MJ, Ottervanger JP, Scholte op Reimer WJM. Hartfalen in de dagelijkse praktijk:patiëntenkenmerken, diagnostiek en behandeling. NTvG 2004;148:943-947. Lenzen MJ, Ottervanger JP, Scholte op Reimer WJM. Hartfalen in de dagelijkse praktijk:patiëntenkenmerken, diagnostiek en behandeling. NTvG 2004;148:943-947.
go back to reference Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW et al. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol 2000; 35(6):1628-1637.CrossRefPubMed Gottdiener JS, Arnold AM, Aurigemma GP, Polak JF, Tracy RP, Kitzman DW et al. Predictors of congestive heart failure in the elderly: the Cardiovascular Health Study. J Am Coll Cardiol 2000; 35(6):1628-1637.CrossRefPubMed
go back to reference Gottdiener JS, McClelland RL, Marshall R, Shemanski L, Furberg CD, Kitzman DW et al. Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study. Ann Intern Med 2002; 137(8):631-639.PubMed Gottdiener JS, McClelland RL, Marshall R, Shemanski L, Furberg CD, Kitzman DW et al. Outcome of congestive heart failure in elderly persons: influence of left ventricular systolic function. The Cardiovascular Health Study. Ann Intern Med 2002; 137(8):631-639.PubMed
go back to reference Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation 2002; 105(11):1387-1393.CrossRefPubMed Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function. Circulation 2002; 105(11):1387-1393.CrossRefPubMed
go back to reference Dahlstrom U. Frequent non-cardiac comorbidities in patients with chronic heart failure. Eur J Heart Fail 2005; 7(3):309-316.CrossRefPubMed Dahlstrom U. Frequent non-cardiac comorbidities in patients with chronic heart failure. Eur J Heart Fail 2005; 7(3):309-316.CrossRefPubMed
go back to reference Van der Wel MC, Bakx JC, Brouwer MA, Straatsma F, Olde Rikkert MGM, van Weel C et al. Geriatric co-morbidity in HF patients aged 65 years and over. J Am Geriatr Soc 53, S111-112. 2005. Van der Wel MC, Bakx JC, Brouwer MA, Straatsma F, Olde Rikkert MGM, van Weel C et al. Geriatric co-morbidity in HF patients aged 65 years and over. J Am Geriatr Soc 53, S111-112. 2005.
go back to reference Havranek EP, Ware MG, Lowes BD. Prevalence of depression in congestive heart failure. Am J Cardiol 1999; 84(3):348-50, A9.CrossRefPubMed Havranek EP, Ware MG, Lowes BD. Prevalence of depression in congestive heart failure. Am J Cardiol 1999; 84(3):348-50, A9.CrossRefPubMed
go back to reference van der Wal MH, Jaarsma T, Van Veldhuisen DJ. Non-compliance in patients with heart failure; how can we manage it? Eur J Heart Fail 2005; 7(1):5-17.CrossRefPubMed van der Wal MH, Jaarsma T, Van Veldhuisen DJ. Non-compliance in patients with heart failure; how can we manage it? Eur J Heart Fail 2005; 7(1):5-17.CrossRefPubMed
go back to reference De GS, Scheurweghs L, Reynders I, Pelemans W, Droogne W, Van CJ et al. Differences in psychosocial and behavioral profiles between heart failure patients admitted to cardiology and geriatric wards. Eur J Heart Fail 2003; 5(4):557-567.CrossRef De GS, Scheurweghs L, Reynders I, Pelemans W, Droogne W, Van CJ et al. Differences in psychosocial and behavioral profiles between heart failure patients admitted to cardiology and geriatric wards. Eur J Heart Fail 2003; 5(4):557-567.CrossRef
go back to reference Komajda M, Follath F, Swedberg K, Cleland J, Aguilar JC, Cohen-Solal A et al. The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. Eur Heart J 2003; 24(5):464-474.CrossRefPubMed Komajda M, Follath F, Swedberg K, Cleland J, Aguilar JC, Cohen-Solal A et al. The EuroHeart Failure Survey programme--a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment. Eur Heart J 2003; 24(5):464-474.CrossRefPubMed
go back to reference Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273(18):1450-1456.CrossRefPubMed Garg R, Yusuf S. Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273(18):1450-1456.CrossRefPubMed
go back to reference Erhardt LR. A review of the current evidence for the use of angiotensin-receptor blockers in chronic heart failure. Int J Clin Pract 2005; 59(5):571-578.CrossRefPubMed Erhardt LR. A review of the current evidence for the use of angiotensin-receptor blockers in chronic heart failure. Int J Clin Pract 2005; 59(5):571-578.CrossRefPubMed
go back to reference Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362(9386):777-781.CrossRefPubMed Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ et al. Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial. Lancet 2003; 362(9386):777-781.CrossRefPubMed
go back to reference Aronow WS, Kronzon I. Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am J Cardiol 1993; 71(7):602-604.CrossRefPubMed Aronow WS, Kronzon I. Effect of enalapril on congestive heart failure treated with diuretics in elderly patients with prior myocardial infarction and normal left ventricular ejection fraction. Am J Cardiol 1993; 71(7):602-604.CrossRefPubMed
go back to reference Yan AT, Yan RT, Liu PP. Narrative review: pharmacotherapy for chronic heart failure: evidence from recent clinical trials. Ann Intern Med 2005; 142(2):132-145.PubMed Yan AT, Yan RT, Liu PP. Narrative review: pharmacotherapy for chronic heart failure: evidence from recent clinical trials. Ann Intern Med 2005; 142(2):132-145.PubMed
go back to reference Bristow MR. beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101(5):558-569.PubMed Bristow MR. beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101(5):558-569.PubMed
go back to reference Waagstein F, Hjalmarson AC, Wasir HS. Apex cardiogram and systolic time intervals in acute myocardial infarction and effects of practolol. Br Heart J 1974; 36(11):1109-1121.CrossRefPubMed Waagstein F, Hjalmarson AC, Wasir HS. Apex cardiogram and systolic time intervals in acute myocardial infarction and effects of practolol. Br Heart J 1974; 36(11):1109-1121.CrossRefPubMed
go back to reference Jansen RW, Gurwitz JH. Controversies surrounding the use of beta-blockers in older patients with cardiovascular disease. Drugs Aging 1994; 4(3):175-183.CrossRefPubMed Jansen RW, Gurwitz JH. Controversies surrounding the use of beta-blockers in older patients with cardiovascular disease. Drugs Aging 1994; 4(3):175-183.CrossRefPubMed
go back to reference Doughty RN, Rodgers A, Sharpe N, MacMahon S. Effects of beta-blocker therapy on mortality in patients with heart failure. A systematic overview of randomized controlled trials. Eur Heart J 1997; 18(4):560-565.PubMed Doughty RN, Rodgers A, Sharpe N, MacMahon S. Effects of beta-blocker therapy on mortality in patients with heart failure. A systematic overview of randomized controlled trials. Eur Heart J 1997; 18(4):560-565.PubMed
go back to reference A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees. Circulation 1994; 90(4):1765-1773. A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees. Circulation 1994; 90(4):1765-1773.
go back to reference The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 1999; 353(9146):9-13. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 1999; 353(9146):9-13.
go back to reference Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999; 353(9169):2001-2007. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999; 353(9169):2001-2007.
go back to reference Deedwania PC, Gottlieb S, Ghali JK, Waagstein F, Wikstrand JC. Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. Eur Heart J 2004; 25(15):1300-1309.CrossRefPubMed Deedwania PC, Gottlieb S, Ghali JK, Waagstein F, Wikstrand JC. Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. Eur Heart J 2004; 25(15):1300-1309.CrossRefPubMed
go back to reference Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996; 334(21):1349-1355.CrossRefPubMed Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996; 334(21):1349-1355.CrossRefPubMed
go back to reference Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001; 344(22):1651-1658.CrossRefPubMed Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P et al. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 2001; 344(22):1651-1658.CrossRefPubMed
go back to reference Poole-Wilson PA, Swedberg K, Cleland JG, Di LA, Hanrath P, Komajda M et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 2003; 362(9377):7-13.CrossRefPubMed Poole-Wilson PA, Swedberg K, Cleland JG, Di LA, Hanrath P, Komajda M et al. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet 2003; 362(9377):7-13.CrossRefPubMed
go back to reference Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A, Borbola J et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26(3):215-225.CrossRefPubMed Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A, Borbola J et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J 2005; 26(3):215-225.CrossRefPubMed
go back to reference Szabo BM, Graeff PA de. Bèta-blokkers bij hartfalen. Geneesmiddelenbulletin 34, 65-70. 2000. Szabo BM, Graeff PA de. Bèta-blokkers bij hartfalen. Geneesmiddelenbulletin 34, 65-70. 2000.
go back to reference Rousseau MF, Chapelle F, Van EC, Stoleru L, Hager D, Van NL et al. Medium-term effects of beta-blockade on left ventricular mechanics: a double-blind, placebo-controlled comparison of nebivolol and atenolol in patients with ischemic left ventricular dysfunction. J Card Fail 1996; 2(1):15-23.CrossRefPubMed Rousseau MF, Chapelle F, Van EC, Stoleru L, Hager D, Van NL et al. Medium-term effects of beta-blockade on left ventricular mechanics: a double-blind, placebo-controlled comparison of nebivolol and atenolol in patients with ischemic left ventricular dysfunction. J Card Fail 1996; 2(1):15-23.CrossRefPubMed
go back to reference Stoleru L, Wijns W, Van EC, Bouvy T, Van NL, Pouleur H. Effects of D-nebivolol and L-nebivolol on left ventricular systolic and diastolic function: comparison with D-L-nebivolol and atenolol. J Cardiovasc Pharmacol 1993; 22(2):183-190.CrossRefPubMed Stoleru L, Wijns W, Van EC, Bouvy T, Van NL, Pouleur H. Effects of D-nebivolol and L-nebivolol on left ventricular systolic and diastolic function: comparison with D-L-nebivolol and atenolol. J Cardiovasc Pharmacol 1993; 22(2):183-190.CrossRefPubMed
go back to reference Nodari S, Metra M, Dei CL. Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension. A prospective, randomized, comparison of the long-term effects of atenolol vs. nebivolol. Eur J Heart Fail 2003; 5(5):621-627.CrossRefPubMed Nodari S, Metra M, Dei CL. Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension. A prospective, randomized, comparison of the long-term effects of atenolol vs. nebivolol. Eur J Heart Fail 2003; 5(5):621-627.CrossRefPubMed
go back to reference Erdmann E, Lechat P, Verkenne P, Wiemann H. Results from post-hoc analyses of the CIBIS II trial: effect of bisoprolol in high-risk patient groups with chronic heart failure. Eur J Heart Fail 2001; 3(4):469-479.CrossRefPubMed Erdmann E, Lechat P, Verkenne P, Wiemann H. Results from post-hoc analyses of the CIBIS II trial: effect of bisoprolol in high-risk patient groups with chronic heart failure. Eur J Heart Fail 2001; 3(4):469-479.CrossRefPubMed
go back to reference Chatterjee K. The fear of beta-blocker therapy in heart failure: time to forget. Arch Intern Med 2004; 164(13):1370-1371.CrossRefPubMed Chatterjee K. The fear of beta-blocker therapy in heart failure: time to forget. Arch Intern Med 2004; 164(13):1370-1371.CrossRefPubMed
go back to reference Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A et al. Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials. Arch Intern Med 2004; 164(13):1389-1394.CrossRefPubMed Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A et al. Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials. Arch Intern Med 2004; 164(13):1389-1394.CrossRefPubMed
go back to reference Witham MD, Gillespie ND, Struthers AD. Age is not a significant risk factor for failed trial of beta-blocker therapy in older patients with chronic heart failure. Age Ageing 2004; 33(5):467-472.CrossRefPubMed Witham MD, Gillespie ND, Struthers AD. Age is not a significant risk factor for failed trial of beta-blocker therapy in older patients with chronic heart failure. Age Ageing 2004; 33(5):467-472.CrossRefPubMed
go back to reference Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF et al. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J 2003; 146(2):250-257.CrossRefPubMed Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF et al. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. Am Heart J 2003; 146(2):250-257.CrossRefPubMed
go back to reference Lopez-Sendon J, Swedberg K, McMurray J, Tamargo J, Maggioni AP, Dargie H et al. Expert consensus document on beta-adrenergic receptor blockers. Eur Heart J 2004; 25(15):1341-1362.CrossRefPubMed Lopez-Sendon J, Swedberg K, McMurray J, Tamargo J, Maggioni AP, Dargie H et al. Expert consensus document on beta-adrenergic receptor blockers. Eur Heart J 2004; 25(15):1341-1362.CrossRefPubMed
go back to reference Willenheimer R, Van Veldhuisen DJ, Silke B, Erdmann E, Follath F, Krum H et al. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation 2005; 112(16):2426-2435.CrossRefPubMed Willenheimer R, Van Veldhuisen DJ, Silke B, Erdmann E, Follath F, Krum H et al. Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III. Circulation 2005; 112(16):2426-2435.CrossRefPubMed
go back to reference Fang JC. Angiotensin-converting enzyme inhibitors or beta-blockers in heart failure: does it matter who goes first? Circulation 2005; 112(16):2380-2382.CrossRefPubMed Fang JC. Angiotensin-converting enzyme inhibitors or beta-blockers in heart failure: does it matter who goes first? Circulation 2005; 112(16):2380-2382.CrossRefPubMed
Metagegevens
Titel
De oudere patiënt met hartfalen en de rol van bètablokkers bij de behandeling
Auteurs
C. W. Middeljans-Tijssen
R. W. M. M. Jansen
Publicatiedatum
01-04-2006
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Tijdschrift voor Gerontologie en Geriatrie / Uitgave 2/2006
Print ISSN: 0167-9228
Elektronisch ISSN: 1875-6832
DOI
https://doi.org/10.1007/BF03074768