In cases of maternal depression certain complex factors interfere with communication with the child. The present study sought to investigate forms of parent–infant communication in families in which the mother was experiencing postpartum depression. Particular emphasis was placed on analysis of crying patterns and on methods employed by parents to soothe the child. The study sample comprised 15 families in which the mother had a diagnosis of postpartum depression. Semi-structured interviews were performed, followed by qualitative content analysis. Results showed that depressed mothers—and, at times, their husbands—reported difficulties in communication with their child, particularly in distinguishing different types of cries and in ways of soothing the infant. Postpartum depression is discussed as a specific diagnosis, beyond its relational aspect, which affects the family as a whole.